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. Author manuscript; available in PMC: 2017 Sep 10.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2014 Aug 15;5(6):867–881. doi: 10.1002/wrna.1253

Figure 1. Mechanisms of SHAPE Chemistry and Electrophiles Used for Acylation.

Figure 1

(A). Reaction pathway of RNA 2’-O-acylation. LG is short for leaving group. (B) Examples of SHAPE electrophiles developed for RNA structure probing. Blue spheres mark the site of 2’-OH attack.