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. Author manuscript; available in PMC: 2017 Sep 10.
Published in final edited form as: Curr Opin Genet Dev. 2016 Aug 3;38:127–132. doi: 10.1016/j.gde.2016.06.011

Figure 1.

Figure 1

Oxidative damage (a) is alleviated by exercise (b) but not mutational load (WT: wild type littermate control; SED: sedentary PolG; END: endurance exercised PolG mouse muscle). WT are daughters of heteroplasmic PolG mothers, hence relatively high mutant background. See Supplement 2 for experimental details.