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. Author manuscript; available in PMC: 2018 Nov 5.
Published in final edited form as: Mol Cell Endocrinol. 2017 Apr 18;455:103–114. doi: 10.1016/j.mce.2017.03.019

Figure 4. Sco2 mutation alters Complex IV activity and oxygen consumption in adipose tissue.

Figure 4

A) COX activity measured in eWAT (left panel) and sWAT (right panel) homogenates. B) OCR of eWAT (left panel) and sWAT (right panel) (~10 mg pieces) was determined using Seahorse XF24 Flux Analyzer under basal, pyruvate, and FCCP-stimulated respiration conditions. The relative OCR of Sco2 KI/KO are compared to the littermate WT control (*, p < 0.05; **, p < 0.001). For all analyses, the bars depict the mean ± SEM of the OCR of 2–3 tissue pieces/tissue/mice (WT, n=4; Sco2 KI/KO, n=4). Dark bars denote wild-type mice and open bars represent Sco2 KI/KO mice.