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. 2017 Sep 6;8:1085. doi: 10.3389/fimmu.2017.01085

Figure 4.

Figure 4

Role for α7 nAChRs during differentiation of naïve T cells. (A) Schematic drawing of non-specific activation of naïve T cell differentiation via T cell receptor and CD28 in the presence of GST-21, a partial agonist for α7 nAChRs. Differentiation of naïve CD4+ T cells into effector T cells (Th1, Th2, and Th17) and regulatory T cells (Tregs) is dictated by the presence of cytokines shown on the respective arrows (142, 143). GTS-21 may facilitate the expression of transcription factor FoxP3 or TGF-β leading to Treg expansion. IFN-γ, interferon-γ; IL-4, interleukin-4; IL-6, interleukin-6; IL-12, interleukin-12; IL-17, interleukin-17; TGF-β, transforming growth factor-β. (B) Effects of GST-21 on naïve T cell differentiation in α7 nAChR-deficient (α7-KO) and wild-type (WT) mice. Note that GTS-21 upregulated differentiation into Tregs in the WT, but not α7-KO mice. Th1 differentiation was not affected by GTS-21 in the both genotypes. Arranged from study by Kawashima et al. (141).