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. 2017 Sep 6;10:284. doi: 10.3389/fnmol.2017.00284

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Copyright © 2017 Deuis, Dvorakova and Vetter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methods used to assess cold-evoked pain like behaviors and temperature preference in rodents. (A) Acetone evaporation test. Rodents are placed individually in small cages with a mesh or barred floor. Acetone is applied to the hind paw and the nocifensive response(s) is counted, timed or scored. (B) Cold plantar assay. Rodents are placed individually in small enclosures with a glass floor. A cold stimulus is applied to the hind paw using a cut off syringe filled with dry ice or wet ice and the time to paw withdrawal is recorded.