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. 2017 Sep;15(9):1444–1452.e6. doi: 10.1016/j.cgh.2017.02.007

Figure 4.

Figure 4

Immunohistochemical staining for inflammatory cell subsets and IgE in IgG4-RD. (A) Type 1 autoimmune pancreatitis, showing IgE-positive cells (brown) within the inflammatory cell infiltrate (IgE immunohistochemistry, original magnification ×200). (B) IgG4-related sialadenitis, showing mast cells (red; arrows) within the inflammatory cell infiltrate (mast cell tryptase immunohistochemistry, original magnification ×400). (C) Type 1 autoimmune pancreatitis, showing a mast cell (red cytoplasm) expressing surface IgE (pale blue, in contrast to dark blue hematoxylin counterstain; arrow) within the inflammatory infiltrate (mast cell tryptase [red] and IgE [pale blue] double immunohistochemistry, original magnification ×400). (D) Type 1 autoimmune pancreatitis, showing CD20-positive B-cells (red; short arrows) not expressing IgE; and a separate inflammatory cell (not CD20-positive) expressing IgE (pale blue, in contrast to dark blue hematoxylin counterstain; long arrow) within the inflammatory cell infiltrate (CD20 [red] and IgE [pale blue] double immunohistochemistry, original magnification ×400). (E) Nasal polyp, showing CD138-positive plasma cells (bright red; long arrows) and a separate population of CD138-negative and IgE-positive cells (brown; short arrows) within the inflammatory cell infiltrate (CD138 [bright red] and IgE [brown] double immunohistochemistry, original magnification ×400).

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