Supplementary Table 2.
IgE Immunostaining in IgG4-RD Patients and DC
| Disease | Sample type | Specimen type | Mean of 3 IgE-positive cells/HPF | Description of IgE-positive cell staining |
|---|---|---|---|---|
| IgG4-RD | Mesenteric mass in IgG4-FS | R | 7 | Scattered IgE-positive cells, diffuse peripheral and central GC staining, cells in areas of fibrosis |
| Whipples in AIP | R | 18 | Numerous scattered IgE-positive cells with nuclear staining | |
| CBD in AIP and IgG4-SC | R | 7 | Scattered IgE-positive cells only | |
| Submandibular gland in IgG4-SA | R | 12 | Scattered IgE-positive cells and diffuse GC staining | |
| Whipples in AIP | R | 19 | Cell surface and nuclear staining; PC in close proximity | |
| Whipples in AIP | R | 1 | Scattered IgE-positive cells only | |
| Pancreas and CBD in AIP | R | 16 | Scattered diffuse IgE-positive cells, ductal inflammation, duodenum many IgE-positive cells | |
| Liver in IgG4-SC | B | 2 | Scattered IgE-positive cells around portal tracts | |
| Disease controls | Reactive lymph node | R | 1 | Paracortex and medulla staining |
| Gallbladder in chronic cholecystitis | R | 3 | Scattered IgE-positive cells only | |
| Pancreas in chronic pancreatitis | R | 10 | IgE-positive cells accumulate in lymphoid aggregates | |
| CBD and liver specimen in secondary sclerosing cholangitis | R | 8 | IgE-positive cells accumulate in lymphoid aggregates, and in periductal fibrosis | |
| Pancreas in chronic pancreatitis | R | 0 | No IgE-positive cells | |
| Nasal polyp | B | 5 | IgE-positive cells accumulate in lymphoid aggregates and in GC |
NOTE. The specimen, mean IgE count, and cell distribution in tissue sections from IgG4-RD patients (n = 8) and disease controls (n = 6).
B, biopsy; CBD, common bile duct; GC, germinal centers; IgG4-FS, IgG4-mesenteric fibrosclerosis; IgG4-SA, IgG4-related sialadenitis; PC, plasma cells; R, resection.