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. 2017 Sep 6;8:618. doi: 10.3389/fphar.2017.00618

FIGURE 1.

FIGURE 1

Effect of EGCG on serum oxidative stress markers in rats. 8-isoprostane level (A) and advanced oxidation protein products (AOPP) level (B) were significantly increased in CS-exposed group of rats compared to SA group. Oral administration of EGCG significantly decreased 8-isoprostane and AOPP levels compared to CS group. Total antioxidant capacity (T-AOC) (C), total superoxide dismutase (SOD) activity (D), and catalase (CAT) activity (E) were inhibited in CS-exposed rats while EGCG treatment reversed these enzymes activities. CS exposure upregulated the activity of glutathione s-transferase (GST) and EGCG treatment reversed GST activity (F). The results are expressed as means ± SEM; n = 7 each group. SA group, water/sham air; CS group, water/cigarette smoke; EGCG/SA group, EGCG (50 mg/kg)/sham air; EGCG/CS, EGCG (50 mg/kg)/cigarette smoke. ∗p < 0.05, ∗∗p < 0.01 and ∗∗∗p < 0.001 for the comparison between CS and SA group, #p < 0.05, ##p < 0.01 and ###p < 0.001 for the comparison between EGCG/CS and CS group.