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. 2017 Sep 11;3:17058. doi: 10.1038/cddiscovery.2017.58

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The synergistic inhibition effects of combination aspirin and sorafenib in HCC cells. Aspirin- and sorafenib-induced apoptosis and DNA fragmentation in Hep3B and HuH-7 cells, respectively. (a and c) Quantification analysis of total cell death from flow cytometry. Annexin V-PE/7-AAD analysis of Hep3B (a) and HuH-7 (c) cells after treated for 24, 48 and 72 h with study agents. Floating and adherent cells were collected after treatment and analyzed by flow cytometry. Points, mean; bars, S.E. (n=3). (b and d) TUNEL staining of Hep3B (b) and HuH-7 (d) cells after 48 h of treatment with study agents. The bright yellow fluorescence spots indicated the apoptotic cells. Nuclei were counterstained with 7-AAD. TUNEL-stained cells were observed at ×40 magnification and scale bars indicate 50 μm.