Table 2.
Description of cohort and antidepressant groups by serotonin reuptake inhibition. Values are numbers (percentages) of patients unless stated otherwise
| Factor | Cohort (n=317 824) | Antidepressant group
|
||
|---|---|---|---|---|
| Low (n=76 712) | Intermediate (n=139 715) | High (n=101 397) | ||
| Median (interquartile range) observation period (months) | 1.6 (0.7-4.3) | 1.9 (1.0-5.6) | 1.0 (0.4-2.6) | 2.1 (1.0-6.5) |
| Upper gastrointestinal bleed during study | 974 (0.3) | 276 (0.4) | 294 (0.2) | 404 (0.4) |
| Year of study entry: | ||||
| 1992 | 28 782 (9.1) | 11 098 (14.5) | 13 396 (9.6) | 4 288 (4.2) |
| 1993-5 | 92 071 (30.5) | 27 133 (24.3) | 46 564 (33.3) | 23 324 (23.0) |
| 1995-7 | 93 967 (29.6) | 19 874 (35.4) | 40 937 (29.3) | 33 156 (32.7) |
| 1997-8 | 98 054 (30.9) | 18 607 (25.9) | 38 818 (27.8) | 40 629 (40.1) |
| Patient factors: | ||||
| Mean (SD) age (years) | 74.5 (7.5) | 75.1 (7.8) | 74.1 (7.2) | 74.7 (7.6) |
| Female | 205 894 (64.8) | 48 089 (62.7) | 93 473 (66.9) | 64 332 (63.4) |
| Medical history: | ||||
| Diabetes | 41 913 (13.2) | 9 467 (12.3) | 19 233 (13.8) | 13 213 (13.0) |
| Upper gastrointestinal bleeding | 7 420 (2.3) | 1 804 (2.4) | 3 184 (2.3) | 2 432 (2.4) |
| Drug use: | ||||
| Non-steroidal anti-inflammatory drugs | 32 269 (10.2) | 6 824 (8.9) | 17 900 (12.8) | 7 545 (7.4) |
| Acetylsalicylic acid | 23 118 (7.3) | 5 465 (7.1) | 10 311 (7.4) | 7 342 (7.2) |
| Steroids | 9 351 (2.9) | 2 204 (2.9) | 4 363 (3.1) | 2 784 (2.7) |
| Anticoagulants | 8 437 (2.7) | 2 002 (2.6) | 3 176 (2.3) | 3 529 (3.2) |
| Peptic ulcer treatment* | 45 335 (14.3) | 10 660 (13.9) | 19 936 (14.3) | 14 739 (14.5) |
*
Includes H2 receptor antagonists and proton pump inhibitors.