Table A1.
Antidepressants available in Ontario drug benefit programme and their categorisation on basis of drug's affinity for serotonin transporter. From Tatsumi et al29
| Serotonin reuptake inhibition group | Antidepressant | Dissociation constant (SEM) for serotonin transporter (nM) |
|---|---|---|
| High | Paroxetine | 0.13 (0.01) |
| Clomipramine | 0.28 (0.01) | |
| Sertraline | 0.29 (0.01) | |
| Fluoxetine | 0.81 (0.02) | |
| Intermediate | Imipramine | 1.4 (0.03) |
| Fluvoxamine | 2.2 (0.02) | |
| Amitriptyline | 4.3 (0.12) | |
| Venlafaxine | 8.9 (0.3) | |
| Low | Desipramine | 17.6 (0.7) |
| Nortriptyline | 18 (1) | |
| Protriptyline | 19.6 (0.5) | |
| Amoxapine | 58 (2) | |
| Doxepin | 68 (1) | |
| Trimipramine | 149 (6) | |
| Trazodone | 160 (20) | |
| Nefazodone | 200 (20) | |
| Maprotiline | 5800 (200) | |
| Bupropion | 9100 (300) |