Table 2.
Association between PTENP1 gene polymorphisms and risk of gastric cancer (rs7853346).
| Genotype | Cases N (%) | Controls N (%) | Crude OR (95% CI) | P | Adjusted OR (95% CI)∗ | P | P c |
|---|---|---|---|---|---|---|---|
| Overall | 768 | 768 | |||||
| Additive model | 0.79 (0.67–0.94) | 0.007 | 0.80 (0.67–0.95) | 0.011 | 0.033 | ||
| Codominant model | |||||||
| CC | 496 (64.6) | 447 (58.2) | 1 | 1 | |||
| CG | 241 (31.4) | 277 (36.1) | 0.78 (0.63–0.97) | 0.026 | 0.79 (0.63–0.98) | 0.033 | 0.099 |
| GG | 31 (4.0) | 44 (5.7) | 0.63 (0.39–1.02) | 0.060 | 0.65 (0.40–1.06) | 0.087 | 0.261 |
| Dominant model | |||||||
| CC | 496 (64.6) | 447 (58.2) | 1 | 1 | |||
| CG+GG | 272 (35.4) | 321 (41.8) | 0.76 (0.62–0.94) | 0.010 | 0.77 (0.62–0.95) | 0.015 | 0.045 |
| P trend | 0.013 | 0.039 | |||||
| Recessive model | |||||||
| CC+CG | 737 (96.0) | 724 (94.3) | 1 | ||||
| GG | 31 (4.0) | 44 (5.7) | 0.69 (0.43–1.11) | 0.124 | 0.71 (0.44–1.14) | 0.153 | 0.459 |
| Allele | |||||||
| C | 1233 (79.8) | 1171 (76.2) | 1 | ||||
| G | 303 (20.2) | 365 (23.8) | 0.79 (0.66–0.94) | 0.007 | |||
| HWE | 0.900 |
Abbreviations: OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg expectations. ∗Adjusted for age, sex, smoking status, drinking status, residence, hypertension, diabetes, and family history of GC in the logistic regression model. Pc after Bonferroni's correction. P trend for CC, CG, GG, and CG+GG genotypes. The significant results are in bold.