Table 3.
Stratified analyses for PTENP1 genotypes in cases and controls (rs7853346).
| Variable | n CG+GG (%)/n CC (%) for rs7853346 | Allelic odds ratios and 95% confidence intervals for rs7853346 | ||||
|---|---|---|---|---|---|---|
| Cases | Controls | Adjusted OR (95% CI)∗ | P value | I 2 | Heterogeneity P | |
| Age (y) | ||||||
| ≥60 | 153 (19.9)/290 (37.8) | 165 (21.5)/226 (29.4) | 0.72 (0.54–0.96) | 0.026 | ||
| <60 | 119 (15.5)/206 (26.8) | 156 (20.3)/221 (28.8) | 0.82 (0.60–1.12) | 0.203 | 0% | 0.610 |
| Sex | ||||||
| Females | 107 (13.9)/180 (23.4) | 143 (18.6)/176 (22.9) | 0.72 (0.51–1.00) | 0.052 | ||
| Males | 165 (21.5)/316 (41.1) | 178 (23.2)/271 (35.3) | 0.79 (0.60–1.03) | 0.085 | 0% | 0.710 |
| Smoking status | ||||||
| Yes | 71 (9.2)/141 (18.4) | 57 (7.4)/86 (11.2) | 0.76 (0.48–1.22) | 0.254 | ||
| No | 201 (26.2)/355 (46.2) | 264 (34.4)/361 (47.0) | 0.78 (0.61–0.99) | 0.037 | 0% | 0.863 |
| Drinking status | ||||||
| Yes | 58 (7.6)/117 (15.2) | 36 (4.7)/63 (8.2) | 0.87 (0.50–1.49) | 0.603 | ||
| No | 214 (27.9)/379 (49.3) | 285 (37.1)/384 (50.0) | 0.75 (0.60–0.95) | 0.016 | 0% | 0.718 |
| Residence | ||||||
| Rural | 166 (21.6)/274 (35.7) | 186 (24.2)/228 (29.7) | 0.77 (0.59–1.02) | 0.071 | ||
| Urban | 106 (13.8)/222 (28.9) | 135 (17.6)/219 (28.5) | 0.78 (0.57–1.08) | 0.133 | 0% | 0.960 |
| FH | ||||||
| Yes | 20 (2.6)/45 (5.9) | 20 (2.6)/33 (4.3) | 0.69 (0.31–1.55) | 0.371 | ||
| No | 252 (32.8)/451 (58.7) | 301 (39.2)/414 (53.9) | 0.78 (0.62–0.97) | 0.023 | 0% | 0.841 |
OR, odds ratio; CI, confidence interval; FH, family history of GC. ∗Adjusted for age, sex, smoking status, drinking status, residence, hypertension, diabetes, and family history of GC (excluding the stratified factor in each stratum) in the logistic regression model. The significant results are in bold.