Table 4.
Mean (SD) scores for key voice and psychological variables at each visit for treatment and no treatment groups (all patients with baseline data)
| Test or questionnaire | Treatment
|
No treatment
|
Sensitivity score (F value) | Treatment effect (points (95% CI)) | |||||
|---|---|---|---|---|---|---|---|---|---|
| No of patients | Visit 1 (baseline) | Visit 2 or 3 | No of patients | Visit 1 (baseline) | Visit 2 or 3 | ||||
| At completion of treatment (visit 2) | |||||||||
| Psychological distress: | |||||||||
| HADS anxiety | 85 | 6.5 (4.2) | 6.2 (4.4) | 80 | 8.2 (4.2) | 7.9 (4.0) | 0.67 (P=0.416) | 0.30 (−0.43 to 1.04) | |
| HADS depression | 85 | 4.1 (3.5) | 4.0 (3.7) | 80 | 4.6 (3.6) | 4.5 (3.4) | 0.30 (P=0.584) | 0.17 (−0.46 to 0.81) | |
| CIS total score | 99 | 7.6 (7.5) | 103 | 9.2 (9.3) | |||||
| Voice: | |||||||||
| Buffalo overall rating* | 100 | 2.9 (1.0) | 2.4 (1.0) | 103 | 3.0 (1.0) | 2.7 (1.0) | 5.0 (P=0.03) | 0.25 (0.003 to 0.47) | |
| Pitch perturbation† | 97 | 3.1 (2.2) | 2.8 (1.6) | 92 | 2.9 (2.2) | 3.1 (2.2) | 5.7 (P=0.018) | 0.46 (0.008 to 0.84) | |
| Amplitude perturbation† | 97 | 6.1 (4.3) | 5.1 (3.5) | 92 | 6.1 (5.3) | 6.5 (5.5) | 11.9 (P=0.001) | 1.5 (0.64 to 2.3) | |
| VPQ total‡ | 85 | 28.4 (9.0) | 24.2 (8.3) | 81 | 29.4 (8.9) | 26.9 (9.5) | 3.9 (P=0.051) | 1.9 (−0.001 to 3.8) | |
| At completion of follow up (visit 3) | |||||||||
| Psychological distress: | |||||||||
| HADS anxiety | 85 | 6.5 (4.2) | 6.0 (3.9) | 80 | 8.2 (4.2) | 7.2 (4.3) | 0.018 (P=0.893) | 0.006 (−0.88 to 1.01) | |
| HADS depression | 85 | 4.1 (3.5) | 3.8 (3.4) | 80 | 4.6 (3.6) | 4.6 (3.8) | 1.51 (P=0.221) | 0.37 (−0.23 to 0.98) | |
| CIS total score | 99 | 7.6 (7.5) | 7.6 (8.2) | 103 | 9.2 (9.3) | 8.6 (9.7) | 0.63 (P=0.428) | 0.58 (−2.01 to 0.86) | |
| Voice: | |||||||||
| Buffalo overall rating* | 100 | 2.9 (1.0) | 2.4 (1.0) | 103 | 3.0 (1.0) | 3.1 (1.0) | 29.80 (P=0.000) | 0.62 (0.40 to 0.85) | |
| Pitch perturbation† | 97 | 3.1 (2.2) | 2.8 (1.6) | 92 | 2.9 (2.2) | 2.8 (2.3) | 0.140 (P=0.709) | 0.008 (−0.35 to 0.51) | |
| Amplitude perturbation† | 97 | 6.1 (4.3) | 5.0 (4.0) | 92 | 6.1 (5.3) | 5.8 (5.6) | 2.8 (P=0.096) | 0.80 (−0.14 to 1.7) | |
| Score on VPQ‡ | 85 | 28.4 (9.0) | 23.3 (8.3) | 81 | 29.4 (8.9) | 27.7 (9.9) | 12.32 (P=0.001) | 3.69 (1.61 to 5.76) | |
HADS=hospital anxiety and depression scale; CIS=clinical interview schedule; VPQ=vocal performance questionnaire.
*
Buffalo voice profile analysis has an “overall rating” as 1 of 10 items scored 0-5.
†
The higher the score the more dysphonic the voice.
‡
Maximum score=60; the higher the score the more dysphonic the voice.