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. Author manuscript; available in PMC: 2017 Sep 11.
Published in final edited form as: Curr Mol Pharmacol. 2015;9(1):5–26. doi: 10.2174/1874467208666150519113146

Fig. 6. Superposition of region surrounding the Pro 88–Pro 89 peptide bond in the crystal structure of the G89P variant (light gray/green) as compared to the homologous segment from the first FKBP domain of FKBP52 (dark gray/purple).

Fig. 6

The structural changes induced by the cis-peptide linkage in the G89P variant yields a backbone conformation that closely follows that of the first FKBP domain of FKBP52 (PDB code 1N1A). The His 87 sidechain is truncated at Cβ to facilitate visualization of the backbone conformations. Illustration as modified from research originally published [70], the Biochemical Society copyright holder.