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The 5-LO pathway: biosynthesis, signaling, and effect on cardiovascular system. 5-Lipoxygenase (5-LO), leukotriene (LT), cytosolic phospholipase A2 (cPLA2), arachidonic acid (AA), 5-LO-activating protein (FLAP), multidrug resistance protein-1 (MRP1), endothelial cells (ECs), and smooth muscle cells (SMCs).
