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. 2017 Sep 11;3:17059. doi: 10.1038/cddiscovery.2017.59

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Copyright © 2017 The Author(s)

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ER stress inducers (BFA, TM, and TG) trigger the UPR. (A) Western blot for UPR-related protein levels in TC-1 and HeLa cells treated with BFA, TM, and TG. Western blot analysis of total TC-1 and HeLa cells lysates for UPR-related protein expression, and protein levels were compared with those of β-actin. (B) Electron microscopic images showing the ultrastructure of BFA-treated TC-1 cell. (a) Representative image of the normal ultrastructure of PBS-treated TC-1 cell. (b) The ultrastructure of BFA-treated TC-1 cell. (c) High magnification image of the ultrastructure of BFA-treated TC-1 cell; solid arrows highlight the swollen endoplasmic reticulum.