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. 2017 Jul 19;292(36):14786–14795. doi: 10.1074/jbc.M117.786160

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© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 4. — TFEB is activated by UVA to regulate expression of p62 and LC3. A, TFEB and p62 protein levels in NHEKs transfected with siCon or siTFEB treated with sham or UVA irradiation. Shown are TFEB (B), p62 (C), and LC3 mRNA (D) in NHEKs transfected with siCon or siTFEB and treated with sham or UVA irradiation. n.s., not significant; *, p < 0.05; **, p < 0.01. E, qPCR analysis of p62 mRNA in NHEKs treated with sham or UVA radiation with or without actinomycin D (1 μg/ml) for 6 h. F, p62 mRNA levels in PAM212 squamous cell carcinoma cells 6 h after sham or UVA irradiation. G, ChIP analysis of TFEB binding to the p62 promoter in NHEKs treated with sham or UVA irradiation. **, p < 0.01. Error bars, S.D.