COX-2 is induced by UVA concomitant with p62 up-regulation.
A, COX-2 and p62 protein levels in NHEKs treated with sham or UVA irradiation (20 J/cm2). B, p62 and COX-2 protein in PAM212 cells after UVA irradiation (10 J/cm2). Shown is qPCR analysis of p62 and COX-2 protein in NHEKs (C) and PAM212 cells (D). *, p < 0.05; **, p < 0.01. E, COX-2 protein levels in PAM212 cells transfected with shCon and shp62. F, qPCR analysis of COX-2 RNA levels in PAM212 cells transfected with shCon and shp62. ***, p < 0.001. Error bars, S.D.