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IC50 values of inhibition of cytochrome P450 enzymes by diosgenin and dioscin. The assay conditions are described in Materials and Methods.
| Compound | IC50 (μM) 3A4 |
2D6 | 2C19 | 1A2 |
|---|---|---|---|---|
| Diosgenin | 17 ± 4 | NE | NE | NE |
| Dioscin | 33 ± 4 | NE | NE | NE |
| Quinidine* | – | 0.04 ± 0.01 | – | – |
| Ketoconazole* | 0.05 ± 0.01 | – | – | – |
| Tranylcypromine* | – | – | 0.9 ± 0.0 | – |
| Furafylline* | – | – | – | 1.12 ± 0.01 |
Data are expressed as mean ± SD of triplicate samples from one experiment. NE = Not effective up to 50 μg/mL.
Positive controls.
