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Chalcone inhibits S. aureus SrtA activity. (A) The inhibitory effect of chalcone on S. aureus SrtA activity. After pre-incubation with various concentrations of chalcone, followed by adding the model substrate peptide Dabcyl-QALPETGEE-Edans, a microplate reader was used to determine the catalytic activity of each sample. (B) The growth curve of S. aureus treated with the indicated concentrations of chalcone.
