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. Author manuscript; available in PMC: 2017 Sep 11.
Published in final edited form as: Am J Hematol. 2009 Jun;84(6):366–370. doi: 10.1002/ajh.21405

Figure 2.

Figure 2

Laboratory assessment algorithm for VWD or other bleeding disorders. If the initial clinical hemostasis evaluation (see Fig. 1) suggests a bleeding disorder, the “initial hemostasis tests” should be ordered, followed by or along with the next tests (“initial VWD assays”) indicated in the laboratory algorithm. Referral to a hemostasis specialist is appropriate for help in interpretation, repeated testing, and specialized VWD studies. *Correction in the PTT mixing study immediately and after 2-hr incubation removes a factor VIII (FVIII) inhibitor from consideration. Investigation of other intrinsic factors and lupus anticoagulant may also be indicated. †Isolated decreased platelets may occur in VWD Type 2B. ↓Refers to a decrease in function or in the test result compared with the laboratory reference range. Modified from Ref. 2, Fig. 2.