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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Inflammation. 2017 Apr;40(2):645–656. doi: 10.1007/s10753-017-0511-y

Figure 1. Bioinformatic Analysis of PLCβ-2 3′UTR.

Figure 1

A. The PLCβ-2 3′UTR (GenBank NM_177568.3) is 1481 bp long, and harbors two AU–rich elements (AREs) shown in bold. One is the canonical pentamer AUUUA, and the other has two overlapping pentamers. AREs are putative binding sites for RNA-binding proteins such as, TTP, HuR and AUF1 which are involved in regulation of mRNA stability. B. Analysis using TargetScan 7.1 shows that the second ARE is conserved across several mammalian species. Dashes indicate where sequences do not match.