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. 2017 Aug 15;144(16):2994–3005. doi: 10.1242/dev.151712

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© 2017. Published by The Company of Biologists Ltd

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Fig. 3. — Domain regulation by Edn1 and Jagged-Notch signaling. (A) In edn1^−/− mutants, intermediate (I) domain genes are those most strongly downregulated, followed by ventral-intermediate (VI) genes. Ventral (V) and dorsal (D) genes are, on average, unaffected. (B) Edn1 overexpression results in greater upregulation of intermediate than ventral genes. (C) Dorsal genes are downregulated in jag1b^−/− mutants. (D) Overexpression of the Notch intracellular domain (NICD) downregulates ventral, ventral-intermediate, and intermediate genes. See the Materials and Methods for details of statistical analysis. *P<0.05, **P<0.01, ***P<0.001.