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Molecular subtypes of breast cancer

Intrinsic subtype	Clinic-pathological definition
ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor 2.
Luminal A	ER and/or PR positive, HER-2 negative, Ki67<14%
Luminal B
Luminal B (HER-2 negative)	ER and/or PR positive, HER-2 negative, Ki67≥14%
Luminal B (HER-2 positive)	ER and/or PR positive, HER-2 positive, any Ki67
HER-2 overexpression	HER-2 overexpression, ER and PR absent
Triple negative	ER and PR absent, HER-2 negative