Table I.
Significant Kyoto Encyclopedia of Genes and Genomes pathways of DEGs.
| DEGs | Pathway | P-value | Genes |
|---|---|---|---|
| Common upregulated DEGs | hsa04360: Axon guidance | 8.43×10−4 | PLXNA3, SEMA7A, MET, NTN4, SEMA3A, CXCL12, EPHA3 |
| hsa04514: Cell adhesion molecules | 8.17×10−3 | NRXN3, ICAM2, CD4, ITGB2, NECTIN3, PDCD1LG2 | |
| hsa05200: Pathways in cancer | 2.16×10−2 | FGF5, PLCB4, PGF, SLC2A1, MET, BDKRB1, ITGA3, FGF1, CXCL12 | |
| hsa04015: Rap1 signaling pathway | 3.75×10−2 | FGF5, PLCB4, PGF, MET, ITGB2, FGF1 | |
| hsa04810: Regulation of actin cytoskeleton | 3.82×10−2 | FGF5, SCIN, BDKRB1, ITGB2, ITGA3, FGF1 | |
| Common downregulated DEGs | hsa04610: Complement and coagulation cascades | 7.15×10−6 | CD55, THBD, MASP1, CFB, F3, C1R, C1S, F2R |
| hsa04360: Axon guidance | 1.09×10−2 | EPHA4, SEMA6D, NTNG1, EFNA5, UNC5D, SLIT3 | |
| hsa02010: ABC transporters | 1.11×10−2 | ABCA8, ABCC9, ABCA9, ABCA6 | |
| hsa05150: Staphylococcus aureus infection | 1.65×10−2 | MASP1, CFB, C1R, C1S | |
| hsa00140: Steroid hormone biosynthesis | 2.32×10−2 | AKR1C3, AKR1C2, HSD11B1, AKR1C1 | |
| MM-specific upregulated DEGs | hsa04810: Regulation of actin cytoskeleton | 4.79×10−2 | RAC2, MRAS, ITGA8, DIAPH3, ITGA7 |
| MGUS-specific downregulated DEGs | hsa05410: Hypertrophic cardiomyopathy | 1.91×10−2 | SGCD, IGF1, CACNA2D3 |
| hsa05414: Dilated cardiomyopathy | 2.20×10−2 | SGCD, IGF1, CACNA2D3 |
DEG, differently expressed gene; hsa, Homo sapiens; ABC, ATP-binding cassette.