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. 2017 Aug 30;51(4):1320–1330. doi: 10.3892/ijo.2017.4108

Figure 2.

Figure 2

Inhibitory effects on cell proliferation and colony formation when the established MCF10A models and breast cancer cell were treated with PI3K and HER2 inhibitor individually and in combination. (A) cell proliferations were detected with treatment of LY294002 (LY) and/or CP724714 (CP) in four different media. Combination of both inhibitors played drastic role in decreasing cell viabilities of MCF10A/HER2/PIK3CA-H1047R cells. (B) The effect of LY294002 (LY) and/or CP724714 (CP) treatment on colony formations of MCF10A/HER2/PIK3CA-H1047R cell model. Evaluation of inhibitory effect of LY294002 (LY) or/and CP724714 (CP) on cell proliferation (c) and colony formation (D) of HCC1954 cells. For all the experiments in this figure, drug dose (μM) is shown next to the drug name. Data represent the mean ± SD of three independent experiments. Student t-test was used for statistical analysis. *0.05>P>0.01, **0.01>P>0.001, ***P<0.001; ns, not significant.