Table III.

Four common pathways in HER2, mutant PIK3CA and mutant PIK3CA+HER2 overexpression models.

Ingenuity canonical pathways	Common genes
Aryl hydrocarbon receptor signaling	RELA, NFIX, MYC, CTSD, ALDH7A1, TP53, MED1, NQO1, BAX, CYP1B1, CDKN1A, ALDH3B1, NRIP1, HSPB1
AMPK signaling	SMARCD2, MAPK13, ELAVL1, CRTC2, TSC2, PIK3R2, AKT1S1, CPT1A, GRB2, STK11, PPP2R1A, CDKN1A
Protein ubiquitination pathway	USP5, HSPA1A/HSPA1B, SACS, BAG1, USP36, USP19, PSMD3, SKP2, USP31, PSMD11, BAP1, HSPB1, USP21, PSMB3, HLA-A
Hereditary breast cancer signaling	SMARCD2, POLR2C, PIK3R2, TP53, GRB2, POLR2E, CDKN1A, SMARCC1, HLTF, RFC3