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. 2017 Aug 3;14(4):4256–4262. doi: 10.3892/ol.2017.6716

Figure 4.

Figure 4.

Effect of NHE1 and ezrin on drug resistance of MOLT4 cells. (A, B) Cell proliferation in wild-type, scramble siRNA-treated and NHE1 siRNA-treated MOLT4 cells incubated with (A) 0.5 mg/ml or (B) 1 mg/ml DOX. (n=3, *P<0.05) (C) Drug accumulation in wild-type and ezrin-silenced MOLT4 cells using flow cytometry. (D) The effect of ezrin silencing and CCL25 on drug resistance of MOLT4 cells was detected using flow cytometry. The average fluorescence density represents DOX accumulation in MOLT4 cells. (n=3; *P<0.05). siRNA, short interfering RNA; Ev-ve, cells silenced with ezrin-targeted siRNA; NHE1, sodium-hydrogen antiporter 1; CCL25, C-C-motif chemokine ligand 25; DOX, doxorubicin.