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. 2017 Aug 30;51(4):1115–1123. doi: 10.3892/ijo.2017.4110

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Copyright: © Cao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Wnt/β-catenin pathway is regulated by TUG1 through EZH2 and contributes to osteosarcoma tumorigenesis. (A) TUG1 knockdown reduced nuclear β-catenin level, which was restored by EZH2 overexpression. (B) TUG1 knockdown inhibited Wnt/β-catenin pathway activation measured by TOPFlash luciferase reporter assay. EZH2 overexpression re-activated Wnt/β-catenin pathway. (C-E) TUG1 knockdown reduced osteosarcoma cell migration and EMT, which was reversed by LiCl, an activator of Wnt/β-catenin pathway. Error bars indicate s.d. ^**P<0.01, Student's t-test.