Table II.
Diagnostic value of combined markers in discrimination of malignant from benign thyroid tumors.
| Markers | AUC | Cut-off | Spe (%) | Sens (%) | PPV (%) | NPV (%) | Fisher's exact test (10−15) |
|---|---|---|---|---|---|---|---|
| Gal-3/CK19/HBME-1 | 0.994 | >2.5 | 97 | 95 | 97 | 96 | P=1.57 |
| Gal-3/CK19/HBME-1/gal-1 | 0.991 | >2 | 95 | 95 | 95 | 95 | P=1.57 |
| Gal-3/CK19/HBME-1/TPO | 0.991 | >2.5 | 97 | 90 | 97 | 91 | P=16.73 |
| Gal-3/CK19/HBME-1/gal-1/TPO | 0.989 | >2.5 | 97 | 91 | 96 | 91 | P=4.63 |
| Gal-3/CK19 | 0.988 | >3 | 99 | 92 | 98 | 93 | P=5.48 |
| Gal-3/HBME-1/TPO | 0.986 | >2.5 | 94 | 87 | 93 | 88 | P=16.73 |
| Gal-3/CK19/gal-1 | 0.985 | >2 | 97 | 92 | 97 | 93 | P=8.91 |
| Gal-3/HBME-1 | 0.985 | >2 | 95 | 95 | 95 | 95 | P=8.29 |
| Gal-3/CK19/TPO | 0.985 | >2.5 | 92 | 94 | 92 | 91 | P=4.71 |
| Gal-3/HBME-1/gal-1/TPO | 0.985 | >2 | 97 | 91 | 95 | 91 | P=1.01 |
| Gal-3/HBME-1/gal-1 | 0.984 | >2 | 95 | 87 | 95 | 89 | P=6.18 |
| Gal-3/CK19/gal-1/TPO | 0.984 | >2 | 94 | 95 | 94 | 95 | P=1.50 |
| CK19/HBME-1/gal-1 | 0.982 | >2 | 94 | 91 | 94 | 91 | P=7.06 |
| Gal-3/TPO | 0.979 | >2.5 | 92 | 90 | 92 | 91 | P=4.42 |
| Gal-3/gal-1/TPO | 0.979 | >2 | 94 | 82 | 93 | 84 | P=12.86 |
| CK19/HBME-1/gal-1/TPO | 0.979 | >2 | 91 | 90 | 90 | 91 | P=22.82 |
| CK19/HBME-1 | 0.972 | >2 | 89 | 91 | 90 | 91 | P= 14.85 |
| CK19/gal-1 | 0.972 | >2 | 95 | 92 | 95 | 93 | P=7.06 |
| CK19/gal-1/TPO | 0.969 | ≥2.5 | 94 | 90 | 93 | 91 | P=20.51 |
| HBME-1/gal-1/TPO | 0.966 | >2 | 95 | 85 | 95 | 87 | P=12.30 |
| CK19/HBME-1/TPO | 0.966 | >3 | 95 | 87 | 95 | 86 | P=7.68 |
| HBME-1/gal-1 | 0.965 | >2 | 97 | 80 | 96 | 83 | P= 5.16 |
| Gal-3/gal-1 | 0.957 | >0 | 83 | 97 | 85 | 96 | P=11.13 |
| CK19/TPO | 0.949 | >3 | 84 | 86 | 84 | 85 | P=14.29 |
| Gal-1/TPO | 0.942 | >2 | 95 | 84 | 95 | 86 | P=1.91 |
| HBME-1/TPO | 0.936 | >2.5 | 92 | 86 | 92 | 97 | P=1.47 |
AUC, area under the curve; Spe, specificity; Sens, sensitivity; PPV, positive predictive value; NPV, negative predictive value; gal-3. galectin-3; CK19, cytokeratin 19; HBME-1, Hector Battifora Mesothelial Epitope-1; TPO, thyroid peroxidase.