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. 2017 Sep 1;51(4):1135–1145. doi: 10.3892/ijo.2017.4112

Figure 2.

Figure 2

Wnt3a signalling activation is correlated with activation of the Notch3 signalling pathway in HCC. (A) Pearson correlation analysis revealed a correlation between Wnt3a and Notch3 and Hes1. Wnt3a is positively correlated with Notch3 and Hes1 [(A) R=0.3923, P=0.0264; (B) R=0.6862, P<0.001]. In addition, Notch3 expression is positively correlated with MMP-7 and c-Myc expression [(C) R=0.6756, P<0.001; (D) R=0.5359, P=0.0016]. We measured Wnt3a and Notch3 protein content with western blots. High Wnt3a expression was always accompanied by an increase in Notch3 expression (E).