Figure 4.

fog-2(lf) partially phenocopies early aging in C. elegans. The β on each axis is the regression coefficient from the GLM, and can be loosely interpreted as an estimator of the log-fold change. Loss of fog-2 is associated with a transcriptomic phenotype involving 1881 genes. 1040/1881 of these genes are also altered in wild-type worms as they progress from young adulthood to old adulthood, and 905 change in the same direction. However, progression from young to old adulthood in a fog-2(lf) background results in no change in the expression level of these genes. (A) We identified genes that change similarly during feminization and aging. The correlation between feminization and aging is almost 1:1. (B) Epistasis plot of aging vs. feminization. Epistasis plots indicate whether two genes (or perturbations) act on the same pathway. When two effects act on the same pathway, this is reflected by a slope of –0.5. The measured slope was –0.51 ± 0.01.