Figure 1.

Chromosome IV duplication is the most frequent mutational event in a screen for spontaneous hydrogen peroxide resistance mutations. (A) Genome-wide coverage plots are provided for the BY × RM and RM × YPS F₂ progenitors, as well as representative aneuploid or segmental duplication mutants derived from them. Site-specific coverages are scaled to the average per site coverage seen across the entire genome for a given strain. (B) Bar plots show the fraction of sequenced mutants that were disomic for the right arm of chromosome IV both across the entire screen and by individual progenitor.