Table 3.

Multivariate adjusted associations between demographic, lifestyle, and reproductive characteristics with pretreatment CA125 levels^*

Predictor	Coefficient (95% CI)*	Percent difference (95% CI)	P-value
Age (years)
<50	Ref	Ref
50–60	0.03 (−0.04, 0.10)	3.4 (−3.5, 10.7)	0.33
60–70	−0.02 (−0.09, 0.05)	−1.8 (−8.5, 5.4)	0.62
>70	−0.02 (−0.10, 0.06)	−2.2 (−10.0, 6.2)	0.60
Stage
I	Ref	Ref
II	0.24 (0.14, 0.34)	27.0 (14.9, 40.3)	<0.0001
III	0.88 (0.79, 0.97)	141.2 (119.5, 165.0)	<0.0001
IV	1.13 (0.81, 1.45)	209.5 (124.3, 327.1)	<0.0001
Histology/grade
High grade serous	Ref	Ref
Low grade serous	−0.14 (−0.21, −0.07)	−13.1 (−19.3, −6.4)	0.0002
Unknown grade serous	−0.10 (−0.22, 0.02)	−9.4 (−19.5, 2.0)	0.10
High grade endometrioid	−0.21 (−0.33, −0.09)	−18.9 (−28.2, −8.2)	0.0009
Low grade endometrioid	−0.24 (−0.35, −0.13)	−21.5 (−29.5, −12.5)	<0.0001
Unknown grade endometrioid	−0.29 (−0.63, 0.06)	−24.8 (−46.7, 6.2)	0.10
Mucinous	−0.62 (−0.74, −0.49)	−46.2 (−52.5, −39.0)	<0.0001
Clear cell	−0.46 (−0.57, −0.35)	−36.6 (−43.2, −29.2)	<0.0001
Other/unknown	−0.18 (−0.27, −0.09)	−16.3 (−23.4, −8.5)	<0.0001
Family history of ovarian cancer
No	Ref	Ref
Yes	0.03 (−0.11, 0.17)	3.4 (−10.0, 18.7)	0.64
Family history of breast cancer
No	Ref	Ref
Yes	0.05 (−0.03, 0.13)	4.9 (−3.3, 13.9)	0.25
BMI (kg/m2)
< 18.5	0.12 (−0.07, 0.30)	12.6 (−6.5, 35.5)	0.25
18.5–25	Ref	Ref
25–30	−0.01 (−0.08, 0.06)	−1.2 (−7.8, 5.9)	0.73
>30	0.09 (0.01, 0.16)	9.1 (1.0, 17.8)	0.03
Ever pregnant
No	Ref	Ref
Yes	−0.04 (−0.12, 0.04)	−3.9 (−11.1, 3.8)	0.29
Tubal ligation
No	Ref	Ref
Yes	0.03 (−0.07, 0.13)	2.8 (−6.9, 13.4)	0.59
Endometriosis
No	Ref	Ref
Yes	−0.05 (−0.16, 0.06)	−5.0 (−14.7, 5.7)	0.34
Race
White	Ref	Ref
Non-white	0.13 (0.03, 0.23)	13.7 (2.9, 25.6)	0.01

^*Estimates are adjusted for all variables listed in the table.