TABLE 1.

Characteristics of included trials in the meta-analysis of the effect of anthocyanins on cardiometabolic health¹

Study (ref), year	Cardiometabolic disease	Subjects, n, T/C	Duration	Intervention material	Total dose2	Anthocyanin, mg/d
Soltani et al. (19), 2015	T2DM	30/30	6 wk	Cornus mas L. fruit extracts	500 mg × 4	600
Li et al. (20), 2015	T2DM	29/29	24 wk	Purified anthocyanins	320 mg	307.2
Lee et al. (21), 2008	T2DM	15/15	12 wk	Cranberry extracts	1500 mg	NA
Kianbakht et al. (22), 2013	T2DM	37/37	4 wk	Whortleberry extracts	1050 mg	7.35
Fukuda et al. (23), 2015	T2DM	41/39	8 wk	Brazilian green propolis	226.8 mg	NA
Shidfar et al. (24), 2012	T2DM	29/29	12 wk	Cranberry juice	240 mL	NA
An et al. (25), 2016	Prediabetes	17/13	12 wk	Black raspberry extracts	1800 mg	NA
Wright et al. (26), 2013	Overweight and obesity	8/8	4 wk	Dried purple carrot	8.3 g × 3	118.5
Stull et al. (27), 2010	Obesity	15/17	6 wk	Blueberry powder	45 g	668
Rebello et al. (28), 2015	Overweight and obesity	14/14	4 wk	Blueberry anthocyanins	8.8 g × 2	325
Davinelli et al. (29), 2015	Overweight	26/16	4 wk	Maqui berry extracts	450 mg	162
Basu et al. (30), 2014 (LD)	Abdominal adiposity	15/15	12 wk	Freeze-dried strawberries	494 mL	78
Basu et al. (30), 2014 (HD)	Abdominal adiposity	15/15	12 wk	Freeze-dried strawberries	494 mL	155
Lee et al. (31), 2016	Overweight and obesity	32/31	8 wk	Black soybean extracts	2500 mg	162.5
Basu et al. (32), 2011	Metabolic syndrome	15/16	8 wk	Cranberry juice	480 mL	24.8
Basu et al. (33), 2010	Metabolic syndrome	25/23	8 wk	Freeze-dried blueberries	480 mL	742
Gurrola-Diaz et al. (34), 2010	Metabolic Syndrome	18/11	31 d	Hibiscus sabdariffa extracts	100 mg	19.24
Jeong et al. (35), 2014	Metabolic syndrome	39/38	12 wk	Black raspberry extracts	750 mg	NA
Puupponen-Pimiä et al. (36), 2013	Metabolic syndrome	20/12	12 wk	Berry constituents	300 g	70.7
Stull et al. (37), 2015	Metabolic syndrome	23/21	6 wk	Blueberry	45 g	580.6
Kianbakht et al. (38), 2014	Dyslipidemia	40/40	2 mo	Whortleberry extracts	1050 mg	7.35
Qin et al. (39), 2009	Dyslipidemia	60/60	12 wk	Purified anthocyanins	320 mg	307.2
Soltani et al. (40), 2014	Hyperlipidemia	25/25	4 wk	Vaccinium arctostaphylos extracts	1000 mg	90
Zhu et al. (41), 2013	Hypercholesterolemia	73/73	24 wk	Purified anthocyanins	320 mg	307.2
Zhang et al. (42), 2015	NAFLD	34/29	12 wk	Purified anthocyanins	320 mg	307.2
Asgary et al. (43), 2014	Hypertension	11/10	2 wk	Pomegranate juice	150 mL	8.7
Erlund et al. (44), 2008	Cardiovascular risk	35/36	8 wk	Berry constituents	150 g	515
Sumner et al. (45), 2005	Coronary heart disease	26/19	3 mo	Pomegranate juice	240 mL	NA
Karlsen et al. (46), 2007	None	59/59	3 wk	Purified anthocyanins	300 mg	300
Duthie et al. (47), 2006	None	11/9	2 wk	Cranberry juice	750 mL	2.2
Murkovic et al. (48), 2004	None	17/17	2 wk	Elderberry juice	1200 mg	120
Novotny et al. (49), 2015	None	29/27	8 wk	Cranberry juice	480 mL	21
Lynn et al. (50), 2014	None	25/21	6 wk	Tart cherry juice	250 mL	273.5

¹Duration refers to the duration of treatment. HD, high dose; LD, low dose; NA, not available; NAFLD, nonalcoholic fatty liver disease; ref, reference; T/C, treatment/control; T2DM, type 2 diabetes.

²Amounts shown are for 1 dose/d unless otherwise indicated.