Table 2. Cases of Prevalent Severe DR and Incident Cardiovascular Outcomes Included in This Meta-analysis.
| DR Type or Outcome | Study, Participants, No. (%) | |||||||
|---|---|---|---|---|---|---|---|---|
| ARIC | AusDiab | BDES | BMES | CHS | LALES | MESA | WESDR | |
| Type | ||||||||
| DME | 9 (0.5) | 11 (1.3) | 13 (2.9) | 12 (4.3) | 6 (1.5) | 119 (9.6) | 48 (6.1) | 136 (7.6) |
| PDR | 313 (17.0) | 7 (0.9) | 14 (3.1) | 4 (3.1) | 8 (2.0) | NA | 8 (1.0) | 115 (6.5) |
| VTDR | 321 (17.4) | 14 (1.7) | 24 (5.4) | 15 (5.3) | 10 (2.5) | 119 (9.6) | 50 (6.3) | 198 (11.2) |
| Outcome | ||||||||
| First CVD | 379 (20.6) | 63 (7.7) | 147 (33.0) | 62 (22.1) | 133 (33.8) | 87 (4.7) | 37 (4.6) | 295 (16.6) |
| Fatal CVD | 29 (1.6) | 31 (3.8) | 82 (18.4) | 49 (17.4) | 90 (22.2) | NA | 5 (0.6) | NA |
| First CHD | 287 (15.6) | 55 (6.7) | 125 (28.0) | 48 (17.1) | 99 (24.4) | 59 (4.8) | 33 (4.2) | 210 (11.8) |
| Fatal CHD | 29 (1.6) | 25 (3.1) | 70 (15.7) | 39 (13.9) | 75 (18.5) | NA | 4 (0.5) | NA |
Abbreviations: ARIC, Atherosclerosis Risk in Communities; AusDiab, Australian Diabetes, Obesity, and Lifestyle Study; BDES, Beaver Dam Eye Study; BMES, Blue Mountains Eye Study; CHD, coronary heart disease; CHS, Cardiovascular Health Study; CVD, cardiovascular disease; DME, diabetic macular edema; DR, diabetic retinopathy; LALES, Los Angeles Latino Eye Study; MESA, Multi-Ethnic Study of Atherosclerosis Study; NA, not applicable; PDR, proliferative diabetic retinopathy; VTDR, vision-threatening diabetic retinopathy; WESDR, Wisconsin Epidemiologic Study of Diabetic Retinopathy.