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. 2017 Jul 8;10(5):412–420. doi: 10.1111/cts.12480

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© 2017 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Influence of Oat1 or Oat3 loss on cisplatin‐induced nephrotoxicity. Levels of blood urea nitrogen (a) or serum creatinine (b) in wildtype or Oat1(–/–) mice (e,f for Oat3(–/–) mice) before and after cisplatin (30 mg/kg). (c) H&E staining of kidneys isolated from wildtype or Oat1(–/–) mice (g for Oat3(–/–) mice) 72 h after cisplatin. (d) Degree of nephrotoxicity based on histology scores observed in kidneys isolated from wildtype or Oat1(–/–) mice (h for Oat3(–/–) mice) 72 h after receiving cisplatin. Toxicity scores are based on percentage of damaged tubules: 0 (<10%; absent), 1 (11–25%; minimal), 2 (26–50%; mild), 3 (51–75%; moderate), and 4 (>75%; severe). All data are represented by mean values (bars) and SD (error bars), using n = 6 samples per group. The star (*) represents P < 0.05 vs. the corresponding wildtype group.