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. 2017 Jul 8;10(5):412–420. doi: 10.1111/cts.12480

Figure 4.

Figure 4

Contribution of OAT1 and OAT3 to renal transport of cisplatin metabolite NAC‐1. (a) Proposed OCT2‐dependent and ‐independent mechanisms of cisplatin‐induced nephrotoxicity. Involvement of OAT1 (b) and OAT3 (c) in the uptake of NAC‐1 (10 μM; 5‐min uptake) in the presence and absence of probenecid in transfected HEK293 cells. Data represent mean values (bars) and SD (error bars) using n = 6 samples per group, and were normalized to NAC‐1 uptake in the absence of probenecid in cells transfected with an empty vector (VC). The star (*) represents P < 0.05 vs. the VC group.