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. 2017 Sep 8;13:1744806917730212. doi: 10.1177/1744806917730212

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Effects of CXCR2 blockade on TBI-induced nociceptive sensitization. (a) systemic adminsitration of SCH527123 (SCH, 1 or 5 mg/kg, i.p.) was performed daily from day 0 to day 7 beginning immediately after TBI. Nociceptive sensitivity was assessed using von Frey fibers 1 h after daily SCH injections during the treatment period. (b) Lumbar intrathecal injection of SCH, 2 µg in 2 µL, on the effects of TBI-induced nociceptive sensitization in day 2 and day 7 injury animals was tested from 0 to 2 h after injection. Threshold values are expressed as mean ± SEM, N = 6. **p < 0.01; ***p < 0.001 comparison of contralateral paws in vehicle-treated rats to the paws of SCH-treated animals; ^###p < 0.001 comparison of SCH-treated groups to sham + vehicle groups. TBI: traumatic brain injury; SCH: SCH527123.