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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Endocr Relat Cancer. 2017 Jun 29;24(8):393–404. doi: 10.1530/ERC-17-0107

Figure 1.

Figure 1

Androgen biosynthesis and metabolism in patients with prostate cancer. 3α-Adiol, 5α-androstane-3α,17β-diol; 3β-adiol, 5α-androstane-3β,17β-diol; 5-adiol, 5-androstene-3β,17β-diol; Adione, 5α-androstane-3,17-dione; Δ4-AD, Δ4-androstene-3,17-dione; AST, androsterone; DHEA, dehydroepiandrosterone; DHT, 5α-dihydrotestosterone; -G, glucuronide; -S, sulfate. Enzymes are identified by their gene names which are in italics. AKR1C1, 20α-hydroxysteroid dehydrogenase; AKR1C2, type 3 3α-hydroxysteroid dehydrogenase; AKR1C3, type 5 17β-hydroxysteroid dehydrogenase; CYP11A1, cytochrome P450 11A1; CYP17A1, cytochrome P450 17A1; HSD3B1, type 1 3β-hydroxysteroid dehydrogenase; HSD17B6, type 6 17β-hydroxysteroid dehydrogenase; SRD5A, 5α-reductase; STS, sulfatase; SULT, sulfotransferase.

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