Skip to main content
. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Mar 29;1861(7):1825–1832. doi: 10.1016/j.bbagen.2017.03.020

Scheme 1.

Scheme 1

Truncation of parent aptamer R1 to generate variants with shorter lengths. Twenty bases were removed from parent aptamer R1 to design R1.1, followed by 17 bases from the 3’- end of R1.1 to design R1.2. Finally, 7 more bases were removed from the 3’-end of R1.2 to generate R1.3. Arrow indicates truncated position in each sequence. A complete list of sequences can be found in Scheme S1. The 2-dimensional structures were obtained from http://rna.urmc.rochester.edu/RNAstructureWeb/index.html.