Table 3.

Risk Factors for Aggravation of Atrophic Gastritis at Follow-up Endoscopy (n=2,144)

	No change (n=1,006)	Aggravation (n=1,138)	HR*	95% CI	HR†	95% CI
Age, yr
<55	617	636	Reference		Reference
≥55	389	502	1.175	1.045–1.321	1.234	1.065–1.430
Sex
Female	330	367	Reference		Reference
Male	676	771	0.973	0.859–1.102	0.900	0.748–1.084
Smoking, pack-year‡	11.38±15.77	12.85±17.70	1.001	0.997–1.005	0.999	0.995–1.004
Alcohol intake, drinks/wk§	7.23±11.65	7.41±12.55	1.011	1.006–1.017	1.001	1.001–1.002
Family history of GC||
No	644	789	Reference		Reference
Yes	100	167	1.050	0.888–1.241	1.032	0.855–1.245
H. pylori infection¶
No	159	96	Reference		Reference
Newly infected	37	44	1.427	0.999–2.040	1.186	0.788–1.785
Eradicated	177	143	1.167	0.901–1.512	1.042	0.769–1.412
Persistent	437	685	1.865	1.506–2.310	1.580	1.220–2.046

HR, hazard ratio; CI, confidence interval; GC, gastric cancer; H. pylori, Helicobacter pylori.

^*Univariate analyses of risk factors for atrophic gastritis;

^†Adjusted for age, sex, smoking, alcohol intake, family history of GC, and H. pylori infection status;

^‡Data available for 1,431 subjects;

^§Data available for 1,586 subjects;

^||Data available for 1,700 subjects;

^¶Data available for 1,778 subjects.