Table 1.
Clinical Characteristics of 30 Patients with Chronic Hepatitis C and Hemophilia
| Characteristic | HCV genotype 1b | HCV genotype 1a | HCV genotype 2a/2b | |
|---|---|---|---|---|
|
| ||||
| RAV (−) | RAV (+) Y93H | |||
|
|
|
|
|
|
| DCV and ASV (n=18) | LDV/SOF (n=3) | LDV/SOF (n=5) | SOF and RBV (n=4) | |
| Age, yr | 45 (32–75) | 53 (44–61) | 42 (30–53) | 53 (44–63) |
| Male sex | 18 (100) | 3 (100) | 5 (100) | 4 (100) |
| BMI, kg/m2 | 23.1 (19.1–31.0) | 27.0 (21.8–31.6) | 26.0 (18.7–41.6) | 20.3 (16.9–23.4) |
| HCV RNA, log10 IU/mL | 6.2 (5.4–6.8) | 6.4 (6.1–6.7) | 6.9 (6.5–7.1) | 5.9 (4.2–7.0) |
| Prior HCV treatment | ||||
| Treatment-naïve | 11 (61.1) | 1 (33.3) | 2 (40.0) | 2 (50.0) |
| Relapse | 5 (27.8) | 2 (66.7) | - | - |
| Breakthrough | - | - | - | - |
| Intolerance | - | - | 1 (20.0) | 2 (50.0) |
| Nonresponse | 2 (11.1) | - | 2 (40.0) | - |
| Cirrhosis | 2 (11.1) | 1 (33.3) | 1 (20.0) | 0 |
| Treatment-naïve | 1 (5.6) | - | - | - |
| Relapse | - | 1 (33.3) | - | - |
| Nonresponse | 1 (5.6) | - | 1 (20.0) | - |
| ALT, U/L | 78.1 (32–207) | 56.7 (46–74) | 68 (19–154) | 23.2 (16–30) |
| Hemoglobin, g/dL | 13.7 (10.0–15.5) | 14.1 (12.7–14.9) | 13.6 (12.4–14.6) | 13.5 (12.0–14.5) |
Data are presented as mean (range) or number (%).
HCV, hepatitis C virus; RAV, resistance-associated variant; DCV, daclatasvir; ASV, asunaprevir; LDV/SOF, ledipasvir/sofosbuvir; RBV, ribavirin; BMI, body mass index; ALT, alanine aminotransferase.