Table 3.

Univariate and multivariate logistic regression analysis of independent factors associated with outcomes in cancer patients treated with colistin for XDR-AB (n=102)

Outcome and variable	Crude OR	95% CI	p-value	Adjusted OR	95% CI	p-value
Clinical response
Loading dose colistin	1.23	0.51–2.97	0.644	1.03	0.38–2.75	0.948
Age ≥60 years	0.77	0.35–1.69	0.519	1.13	0.46–2.80	0.780
Septic shock	0.30	0.13–0.70	0.005	0.26	0.10–0.64	0.004
Baseline SCr ≥1 mg/dl	0.61	0.26–1.43	0.263	0.68	0.26–1.77	0.437
Charlson score ≥4	0.82	0.69–0.98	0.029	0.40	0.16–0.98	0.047
Duration of colistin ≥10 day	1.04	0.43–2.46	0.929	2.83	1.17–6.81	0.020
Microbiological response
Loading dose colistin	2.2	0.88–5.49	0.091	2.27	0.84–6.13	0.105
Age ≥60 years	0.81	0.35–1.89	0.631	1.09	0.42–2.80	0.850
Septic shock	0.31	0.12–0.79	0.015	0.28	0.10–0.78	0.015
Baseline SCr ≥1 mg/dl	1.00	0.41–2.48	0.02	1.30	0.47–3.53	0.606
Charlson score ≥4	0.92	0.39–2.15	0.844	0.93	0.37–2.33	0.882
Duration of colistin ≥ 10 days	2.22	1.00–4.91	0.048	2.49	0.98–6.32	0.054
Nephrotoxicity
Loading dose colistin	2.59	1.05–6.40	0.039	5.80	1.45–23.25	0.013
Age ≥60 years	2.05	0.89–4.67	0.088	3.28	1.09–9.87	0.034
Use vasopressor drug	1.57	0.68–3.63	0.287	1.76	0.63–4.90	0.278
Baseline SCr ≥1 mg/dl	0.58	0.24–1.39	0.229	0.60	0.20–1.86	0.385
Duration of colistin ≥10 days	1.11	0.44–2.75	0.820	0.58	0.22–1.53	0.274

Abbreviations: XDR-AB, extensively drug-resistant Acinetobacter baumannii; OR, odds ratio; CI, confidence interval; SCr, serum creatinine.

Note: Bold indicates data is significant (p<0.05).