Table 1.
Compositions of different WGA-TA sHDLs and corresponding encapsulation efficiency (EE)
| Lipid composition | DPPC (mg) |
SM (mg) |
DMPC (mg) |
POPC (mg) |
22A (mg) |
WGA-TA | EE% |
|---|---|---|---|---|---|---|---|
| DPPC | 20 | 0 | 0 | 0 | 10 | 0.3 | 45 |
| SM | 0 | 20 | 0 | 0 | 10 | 0.3 | 45 |
| DMPC | 0 | 0 | 20 | 0 | 10 | 0.3 | 31 |
| DPPC/SM | 10 | 10 | 0 | 0 | 10 | 0.3 | 50 |
| DMPC/POPC | 0 | 0 | 10 | 10 | 10 | 0.3 | 78 |
Abbreviations: WGA-TA, withalongolide A 4,19,27-triacetate; sHDLs, synthetic high-density lipoproteins; DPPC, dipalmitoylphosphatidylcholine; SM, sphingomyelin; DMPC, dimyristoylphosphatidylcholine; POPC, palmitoyloleoylphosphatidylcholine.