Table II.
Degrees of differential expression and targets of the 19 differentially expressed miRNAs.
| miRNA | Degree | Targets |
|---|---|---|
| miR-125a-5p | 22 | ENTPD2, CXCL12, GAS6, YPEL4, ARC, CHP2, GRB10, ITGA7, CYGB, SLC4A10, HAS1, WISP2, OLFML2A, LZTS1, TNFRSF11B, ADAMTS1, EMP2, APOLD1, RHOV, VEGFB, CLIC5, ITPKC |
| miR-195-5p | 20 | NKD1, DLL1, PLCXD2, ADRA1D, GK, SLC16A6, WIF1, ITGA2, SNX33, PLA2G15, FLRT3, TPPP3, MMP17, ADCY5, RUNX1T1, ISLR, DYRK1B, PTHLH, PTPN4, PTH |
| miR-497-5p | 19 | DLL1, ITGA2, NKD1, GK, PTH, ADRA1D, ISLR, PLA2G15, PTHLH, RUNX1T1, SNX33, TPPP3, MMP17, SLC16A6, PLCXD2, ADCY5, DYRK1B, WIF1, PTPN4 |
| miR-27b-3p | 18 | PPARG, RND3, ZFP36L1,PPAP2B, FAM171A1, EPB41L1, HEG1, FLRT3, GATA2, NOVA1, STK39, EEPD1, WIPF3, SPRY2, PLCXD2, STMN2, DCX, PKIA |
| miR-15a-5p | 12 | ISLR, RUNX1T1, DLL1, PTH, PTHLH, TPPP3, GK, NKD1, ITGA2, ADRA1D, PLA2G15, MMP17 |
| miR-10a-5p | 9 | ADRA1D, RBMS3, LZTS1, KAZALD1, SH3D19, KLF4, EEPD1, LTBP1, PPP1R14C |
| miR-218a-5p | 9 | FLRT3, SH3D19, PLA2G15, CALCRL, KCNH1, PLCXD2, NDRG4, FAM63B, LHFP |
| miR-92a-3p | 9 | FAM110B, GATA2, NOVA1, SLC32A1, STK39, KLF4, PRKAR1B, KLF6, GPM6A |
| miR-128-3p | 8 | EFEMP1, DCX, SCML4, RND3, IL17RE, ITPKC, KLF4, ABCB9 |
| miR-19b-3p | 8 | GULP1, SH3D19, HSPA2, RBMS3, HEG1, GRB10, ENC1, ARC |
| miR-23b-3p | 7 | KCNH1, DLG2, CXCL12, LOC499602, CAV2, NACC2, NAP1L5 |
| miR-204-5p | 6 | NAT8L, LRRN4CL, DHH, NOVA1, HEG1, RGD1562629 |
| miR-143-3p | 5 | DYRK1B, CXCL12, CLIC5, WFDC1, PTPN4 |
| miR-133b-3p | 4 | EMP2, ENC1, CNTNAP1, GPM6A |
| miR-142-5p | 4 | RERG, JAM2, CNTLN, GCH1 |
| miR-196a-5p | 4 | PLCXD2, RBMS3, PBX1, ABCB9 |
| miR-196b-5p | 4 | RBMS3, PLCXD2, PBX1, ABCB9 |
| miR-10b-5p | 1 | GPM6A |
| miR-486 | 1 | BTBD3 |
Genes mentioned in the main text: miR, microRNA; GAS6, growth arrest specific 6; VEGFB, vascular endothelial growth factor B; JAM2, junctional adhesion molecule 2; CXCL12, C-X-C motif chemokine ligand 12; APOLD1, apolipoprotein L domain containing 1; HSPA2, heat shock protein family A (Hsp70) member 2; DLL1, delta like canonical Notch ligand 1; GATA2, GATA binding protein 2; KLF4, Kruppel like factor 4; ITGA2, integrin subunit α2.