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. 2017 Aug 9;40(4):965–971. doi: 10.3892/ijmm.2017.3093

Figure 1.

Figure 1

Structure of Kidins220 and its binding interaction partners. Schematic structure of Kidins220 scaffold protein. An archetypal Kidins220 scaffold protein contains multiple protein binding domains and post-translational modified sites, through which Kidins220 coordinates signal transduction of various pathways, such as Trk and MAPK. The scaffolding role of Kidins220 appears to be directed based on the different binding partners within the protein. Kidins2202, kinase D-interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning; SAM, sterile α motif; MAP, microtubule-associated protein; KIM, kinase light chain (KLC)-interacting motif; PDZ, PSD-95, Dlg, ZO-1-binding motif; Trks, tropomyosin receptor kinase; NGFR, nerve growth factor receptor; VEGFR, vascular endothelial growth factor receptor.