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. 2017 Aug 15;6:e26138. doi: 10.7554/eLife.26138

Figure 2. Activation of μ-opioid receptors inhibits TRPM3.

Figure 2.

(a) Effect of the selective μ opioid receptor agonist DAMGO, δ opioid receptor agonist SB205607 and κ opioid receptor agonist U50488 (each at 20 nM) on [Ca2+]i-responses evoked by PS (20 µM, second application, see Figure 1 for protocol). *p<0.05, ***p<0.001; Kruskal-Wallis (control, n = 152; DAMGO, n = 184; SB205607, n = 200; U50488, n = 140). (b) Traces displaying the effect of DAMGO (20 nM) on neuronal [Ca2+]i responses to stimulation with PS (20 µM). F(340/380) indicates fura-2 emission ratio. (c) Pseudocolour images illustrating the change in F340/380 ratio in response to PS and KCl with the colours corresponding to various F340/380 values indicated by the bar.

DOI: http://dx.doi.org/10.7554/eLife.26138.004