Figure 9. Nociceptive responses to TRPM3 agonists are modulated by Gi GPCR ligands.
(a,b) Inhibitory effects of prior (5 min) intraplantar administrations of (a) 130 nmole morphine (n = 6 for each group) and (b) 240 nmole baclofen (n = 6) or 235 pmole PYY (n = 8) on the duration of licking/flinching evoked by intraplantar injection of 5 nmole PS plus 0.5 nmole CIM-0216 (n = 10 for PS + CIM0216). (c,d) Effects of prior (30 min) intraperitoneal administration of either (c) 2.5 mg/kg naloxone (n = 9 for PS, n = 8 for PS + naloxone) or (d) 3 mg/kg BIIE 0246 (n = 11 for PS, n = 8 for PS + BIIE 0246) on licking/flinching behaviour evoked by intraplantar administration of 5nmole PS. *p<0.05, **p<0.01, ***p<0.001; ANOVA followed by Tukey’s HSD test. (e) No effect of intraplantar morphine (130 nmole) on nociceptive responses evoked by intraplantar administration of capsaicin (33 nmole). Vehicle, 0.9% NaCl.